Today’s synthesis planning for drug discovery relies on connecting the wisdom and practical expertise of an experienced organic chemist with the automation and advanced algorithms found in modern retrosynthesis software. This five-part series, sponsored by MilliporeSigma, will enable you to pioneer a pathway to more efficient, sustainable drug discovery. The articles featured here emphasize the importance of retrosynthesis software to help mitigate risk and augment your lab staff’s expertise, offer tips to implement‚ greener‘ chemistry, outline the steps to scale-up a synthesis reaction, and more.

Table Of Contents

• Overcoming Key Challenges in Drug Discovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
• Using High-Throughput Screening to Rapidly Identify Targets. . . . . . . . . . . . . . . . 6
• Three Ways to Improve the Sustainability of Your Lab’s Chemical Synthesis . .9
• How to Scale Up a New Synthesis Reaction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
• Computer-Aided Synthesis Reduces Complexity and Accelerates Novel Chemical Discoveries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16